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Editor's note: We apologize that this issue of Ola Hou was delayed due to technical difficulties. Mahalo for your understanding and support.
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Green voices support for cancer science at Weinman Symposium
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Hawaiʻi Gov. Josh Green is underscoring the critical importance of cancer research and overall medical science as both a humanitarian responsibility, and a matter of national and international security. Green's remarks on January 23 came before nearly 100 people gathered at the University of Hawaiʻi Cancer Center for a roundtable discussion on how cancer research will carry on amid federal funding cuts, held as part of the center’s 17th Annual Barry & Virginia Weinman Symposium. Green also reaffirmed the state’s commitment to supporting UH and the UH Cancer Center, pointing to a plan to provide an additional $7.5 million to the center. The symposium, January 21-23, was led by Dr. Michele Carbone, Co-Founder of the Weinman Symposium and Director, Thoracic Oncology, UH Cancer Center. Click here to read more about the governor’s remarks. Click here and here to learn more about the Weinman Symposium, or go to WeinmanSymposium.com.
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Island Scene highlights hula group from UH Cancer Center
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The latest issue of HMSA’s Island Scene magazine profiles Nā Wāhine Hula ‘Ākala — a hula group that was formed after two UH Cancer Center studies that examined how hula could provide health benefits for survivors of breast and gynecological cancers. While the studies were successfully concluded years ago, the participants built relationships and bonds that continue to bring them together today, to commune, practice, and perform on behalf of the UH Cancer Center. Click here to read the article (starting on page 28). Mahalo to hālau leader TeMoana Makolo and the ladies of Nā Wāhine Hula ‘Ākala for always representing our center with wisdom and grace.
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‘HI Now Daily’ interview with Wilkens spotlights Ho‘ōla EPCRC
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Lynne Wilkens, UH Cancer Center Director of Biostatistics Shared Resource, and Associate Director of Shared Resources, was recently interviewed on HI Now Daily on Hawaii News Now about our new Ho‘ōla Early Phase Clinical Research Center, which opens on March 2. For the first time in Hawai‘i history, qualifying local patients will have the opportunity to access Phase I clinical trial treatments for cancer right here in Honolulu, instead of having to fly to the U.S. continent. Mahalo to the University of Hawai‘i Professional Assembly for inviting our center to be a part of their HNN interview series! Click here to watch the interview.
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Caregivers empowered at Cancer CARE Community event
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Nearly 100 people came for support and education at “Caring for Caregivers,” the January 17 event presented by the Susan C. Hirano Cancer CARE Community at our Sullivan Conference Center. Dr. Kevin Cassel, Associate Director for Community Outreach and Engagement, presented on research and supportive resources; Cancer CARE Community Co-Founder Peter Hirano shared his experience as caregiver for his late wife, Susan; and palliative care physician Dr. Faryal Michaud gave insights and led a journaling exercise. Separate discussion sessions were held for caregivers, and patients/survivors/thrivers. The public is invited to the next event of the Cancer CARE Community, “How Clinical Trials Save Lives,” on April 18 at the center. Details to be announced. Click here for program information.
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Open house by Nutrition Support Shared Resource draws crowd
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Faculty, staff and the public had a chance to learn more about our center's Nutrition Support Shared Resource (NSSR) department and its capabilities and resources at its first open house, held January 20. Attendees were invited to meet the NSSR’s team of researchers, nutritionists and staff, tour the Translational Research Clinic, check out unique tools, experience cooking demonstrations, and sample healthful food from our center’s Metabolic Kitchen. Mahalo to everyone who visited! For more information on the NSSR, click here. To view a video from the open house, click here.
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'How Clinical Trials Save Lives' — Presented by the Susan C. Hirano Cancer CARE Community, UH Cancer Center Saturday, April 18 Sullivan Conference Center, UH Cancer Center Registration details to come
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Current understanding of ENaC regulation by P2Y2/PLC/PI(4,5)P2 pathway. Abd El-Aziz TM, Al-Sabi A, Seale LA, Soares AG.Purinergic Signal. 2026 Jan 7;22(1):2.
Germline HLA heterozygosity is associated with decreased lung cancer risk. Tan T, Shaw VR, Byun J, Lee HS, Han Y, Li Y, Hung RJ, Christiani DC, Wang XA, Johansson M, Xiao X, Zaridze D, Bojesen SE, Shete S, Albanes D, Aldrich MC, Tardon A, Fernandez-Tardon G, Le Marchand L, Rennert G, Bickeböller H, Wichmann HE, Risch A, Field JK, Davies M, Woll P, Kiemeney LA, Haugen A, Zienolddiny S, Lam S, Johansson M, Grankvist K, Schabath MB, Andrew A, Lazarus P, Arnold SM, Zhu D, Landi MT, McKay J, Amos C, Cheng C.HGG Adv. 2026 Jan 12:100567.
Late-Onset Rheumatoid Arthritis and Air Pollution in the Multiethnic Cohort. Wu AH, Tseng C, Park SY, Stram DO, White K, Wu J, Vigen C, Setiawan VW, Yu X, Gazal S, Haiman C, Wilkens L, Le Marchan L, Cheng I, Stohl W. Arthritis Rheumatol. 2026 Jan 12.
Cross-ancestry information transfer framework improves protein abundance prediction and protein-trait association identification. Zhai W, Sun L, Fang W, Dong Y, Cheng C, Liu Y, Zhou Y, Ji J, Wu L, Pan A, Gamazon ER, Pan XF, Zhou D. Brief Bioinform. 2026 Jan 7;27(1):bbaf707.
Predictive value of the Cancer and Aging Research Group Score for chemotherapy toxicities in older adults with cancer: a systematic review and meta-analysis. Horiuchi K, Kuno T, Takagi H, Ueno NT, Afezolli D. Support Care Cancer. 2026 Jan 12;34(2):85.
Fine mapping regulatory variants by characterizing native CpG methylation with nanopore long-read sequencing. Tian Y, McDonnell SK, Wu L, Larson NB, Wang L. HGG Adv. 2026 Jan 15;7(1):100532.
Suicides and Overdoses During the 2023 Wildfires in Maui, Hawai'i-Reply. Purtle J, Kaholokula JK, Ortega AN. JAMA. 2026 Jan 6;335(1):92-93.
A Nested Case-Control Study of Monoclonal Gammopathy of Undetermined Significance in the Multiethnic Cohort Study. Salehi M, Wilkens LR, Wan JY, Cortessis VK, Stram D, Conti DV, Aparicio J, Lam E, Bernstein MP, Desai P, Bertrand KA, Rosenberg AS, Lee L, Le Marchand L, Haiman CA, Emerson J, Cozen W. Blood Adv. 2026 Jan 13:bloodadvances.2024015266.
Investigating the Causal Effect of Potential Therapeutic Agents for Colorectal Cancer Prevention: A Mendelian Randomization Analysis. Fryer E, Bishop DT, Campbell PT, Chan AT, Le Marchand L, Li CI, Moreno V, Gunter MJ, Phipps AI, Grant RC, Schmit SL, Martin RM, Yarmolinsky J, Haycock P. Cancer Epidemiol Biomarkers Prev. 2026 Jan 9;35(1):95-108.
Deoxygenative Difunctionalization of Aldehydes via Ketyl Radical and Light/Dark Pd Synergy. Bian T, Colomer G, Liu Y, Tius MA, Zhang Z. Angew Chem Int Ed Engl. 2026 Jan 16;65(3):e21847.
β-Catenin regulates distinct pathways from YAP and suppresses ONECUT1 to drive hepatoblastoma development in mice and humans. Liao W, Zhang Y, Wang J, Cui G, Evert M, Xu M, Wu Y, Wang X, Deng S, Song X, Monga SP, Zhao J, Li Q, Calvisi DF, Chen X. Hepatology. 2026 Feb 1;83(2):215-230.
Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes. Shimada BK, Ogawa-Wong AN, Soares AG, Hallam KA, Santiago PJD, Saelua K, Nakahara-Akita KK, Torres DJ, Brockman JD, Kurokawa S, Ewell KL, Bellinger MT, Toh P, Lagatta Pamplona Remedios G, Alfulaij N, Swanson SM, Seyedali A, Zavacki AM, Berry MJ, Seale LA. Am J Physiol Endocrinol Metab. 2026 Feb 1;330(2):E000.
Associations of pre- and post-diagnosis dietary macronutrient quality and its changes with ovarian cancer survival: evidence from a prospective cohort study. Li XY, Wei YF, Huang DH, Song XJ, Liu FH, Li YZ, Xu HL, Cao F, Gao S, Wu L, Zhao YH, Cui Q, Gong TT, Wu QJ. Nutr J. 2026 Jan 24;25(1):17.
Diagnostic Accuracy of the Oncuria-Detect Multiplex Immunoassay in Detecting Upper Tract Urothelial Carcinoma. Fujita K, Miyake M, Hashimoto M, Shimizu T, Linehan J, Gottlieb J, Pagano I, Tikhonenkov S, Luu M, Tanaka S, Siguencia F, Murakami K, Lee R, Sakatani T, Rosser CJ, Furuya H. J Urol. 2026 Feb;215(2):174-182.
Dietary Patterns and Prostate Cancer Risk in the Multiethnic Cohort Study. Xiong W, Park SY, Wan P, Wang A, Hughley RW, Le Marchand L, Wilkens LR, Conti DV, Haiman CA, Chen F. Cancer Epidemiol Biomarkers Prev. 2026 Feb 3;35(2):247-254.
Payload Diversification Overcomes Resistance and Guides Sequential Antibody-Drug Conjugate Therapy in Breast Cancer. Rampa DR, Seo M, Ogata N, Yang Z, Sridhar N, Takeo F, Wannaphut C, Maynard JA, Tsuchikama K, Sledge GW, Ueno NT, Lee J. Clin Cancer Res. 2026 Jan 27.
Transgender and other gender minoritised assigned female at birth young adults' perceptions of and experiences with human papillomavirus vaccination. Rhodes A, Ahmadi T, Gordon AR, Murchison GR, Fontenot HB, Potter J, Agénor M. Cult Health Sex. 2026 Feb;28(2):243-258.
Impact of community-based obesity prevention interventions on child and adolescent health-related quality of life: A pooled analysis of six Australian studies. McKenna K, Nichols M, Strugnell C, Orellana L, Allender S, Novotny R, Jacobs J, Brown V. Public Health. 2026 Jan 23;252:106147.
Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses. Han Y, Byun J, VanLith CJ, Cooley MA, Shaw VR, Hatia RI, Ahmed FY, Giama NH, Ali HM, Campbell NA, Hassan M, Andersen JB, Ankoma-Sey V, Banales JM, Bujanda L, Bathe OF, Bekaii-Saab TS, Borad MJ, Björkström NK, Chan CHF, Cleary SP, Cornillet M, Folseraas T, Galle PR, Genkinger JM, MacInnis RJ, Gores GJ, Goyal L, Houlston RS, Ilyas SI, Javle M, Johansen JS, Christensen TD, Kamath AS, Kelley RK, Khan SA, Kim RD, Kwee SA, Lamarca A, Lammert F, LaRusso NF, Lindsey S, Macias RIR, Malhi H, Patel TC, Permuth JB, Reeves HL, Rossi S, Sanchez W, Smoot RL, Swerdlow AJ, Tran Cao HS, Valle JW, Weinmann A, Weinmann-Menke J, Wong LL, Zhang X, Zimmer V, Zhu AX, Lazaridis KN, Juran BD, Jalal P, Knox JJ, Hutchinson A, Hicks B, Koshiol JE, Chanock SJ, Hassan MM, Amos CI, McGlynn KA, Roberts LR. Hepatology. 2026 Feb 2.
The Impact of The 2023 ACS Screening Recommendations on Racial, Ethnic, and Sex Disparities in Lung Cancer Screening Eligibility. Manful A, Amanna N, Park SL, Petrick JL, Rosenberg L, Tindle H, Palmer J, Wilkens L, Le Marchand L, Aldrich MC, Blume JD. Chest. 2026 Jan 22:S0012-3692(26)00122-4.
High levels of circulating miR-19a-3p in patients with metastatic HER2 + breast cancer are associated with a favorable prognosis and anti-tumor immune responses. Cohen EN, Gao H, Tin S, Wu Q, Ivan C, Ueno NT, Woodward WA, Reuben JM, Anfossi S. Breast Cancer Res. 2026 Jan 26;28(1):3.
Comparing body composition techniques against an adapted multicompartment model in individuals with excess body weight. Montenegro J, Bennett JP, Oliveira CLP, Berg A, Sharma AM, Mereu L, Shepherd JA, Siervo M, Walter J, Prado CM. Nutrition. 2026 Mar;143:113033.
Aleutianamine B, A Novel Chiral Sulfoxide Isolated from Latrunculia spp. and Generated via Semi-Synthesis, Exhibits Selectivity for Ovarian Cancer Cells. Dickinson CF, Flipse SM, Wood JS, Bistran E, Bland AM, Sprague DJ, DeJohn AM, Choo YM, Hanna GS, Yoshida WY, Williamson RT, Tius MA, Hamann MT. J Nat Prod. 2026 Jan 23;89(1):73-81.
Does changing the routinely recommended age for HPV vaccination change parental thoughts about vaccinating their adolescent: A mixed-methods analysis. Coad S, Liebermann EJ, Lim E, Matsunaga M, Zimet G, Fontenot HB. Vaccine. 2026 Jan 25;71:128080.
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